PPARA

Summary: PPARA is involved in the homeostasis of lipids in the fasting state as well as during the acute postprandial response to dietary fat. The minor allele carriers displayed lower mean concentrations of TG and cholesterol throughout the postprandial period. These data suggest that PPARA variants may modulate the risk of Cardiovascular disease by influencing both fasting and postprandial lipid.

dbSNP: rs1800206

Disease: Cardiovascular disease

PPARA

Summary: After the high-P:S diet, a significant gene-by-diet interaction was observed for changes in plasma total cholesterol, apolipoprotein (apo) A-I, and cholesterol concentrations in small LDL particles (P

dbSNP: rs1800206

Disease: Dyslipidemia, Atherosclerosis, Obesity, Insulin resistance, and Type-2 Diabetes Mellitus

PPARA

Summary: At baseline, PPARA Leu162Val * PPARG Pro12Ala genotype interaction did not significantly influence plasma lipid concentrations. After dietary intervention, gene-gene interaction significantly influenced LDL cholesterol (p = 0.0002) and small dense LDL as a proportion of LDL (p = 0.005) after adjustments.

dbSNP: rs1800206

Disease: Metabolic syndrome

PPARA

Summary: Following n-3 Polyunsaturated Fats supplementation, plasma TAG concentrations of minor allele carriers of rs1799983 were considerably more responsive to changes in plasma n-3 polyunsaturated Fats, than major allele homozygotes.

dbSNP: rs1800206

Disease: Metabolic syndrome/Cardiovascular disease